张淳
发布时间: 2014-02-23 浏览次数: 398

博士
生物药物研发室主任
E-mail
:eastrocket@163.com

专利:

1.       Chun Zhang, Kai Fan, Xuefeng Ma, Li Yang, Chunlan Hu, Hua Luo, Xiang Me. PEGylated analogue protein of canine urate oxidase, preparation method and uses thereof. PCT Patent, Pub No.:WO/2012/109975.

2.       Kai Fan, Chun Zhang, Xuefeng Ma, Xiang Me, Chunlan Hu. Humanized recombinant uricase and mutants thereof. PCT Patent, Pub No.:WO/2011/050599.

3.       Kai Fan, Zhiquan Zhao, Chun Zhang, Yong Chen, Hua Luo, Li Yang, Honghong Liu. Fusion protein regulations plasma glucose and lipid, its preparation method and use. PCT Patent, Pub No.: WO/2011/020319.

4.       Kai Fan, Zhiquan Zhao, Yong Chen, Chun Zhang, Lin Wang. Homodimer of insulinothropic peptide analogues and method for preparation thereof and use thereof. PCT Patent, Pub No.: WO/2011/020320.

5.       Kai Fan, Yong Chen, Hairong Chen, Chun Zhang, Xiang Mei, Yi Zhang. N-terminal deletion variant of human Fibroblast growth factor 21 and conjugate thereof. PCT Patent, Pub No.: WO/2012/062078.

发表著作、论文情况:

1.       Chun Zhang, Kai Fan, Weitao Zhang, Ruixin Zhu, Lujia Zhang, Dongzhi Wei . Structure-based characterization of canine–human chimeric uricases and its evolutionary implications. Biochimie, 2012, 94(6):1412-1420.

2.       Chun Zhang, Kai Fan, Xuefeng Ma, Dongzhi Wei. Impact of large aggregated uricases and PEG diol on accelerated blood clearance of PEGylated canine uricase. PloS One, 2012, 7(6): e39659.

3.       Chun Zhang, Kai Fan, Hua Luo, Xuefeng Ma, Riyong Liu, Li Yang, Chunlan Hu, Zhenmin Chen, Zhiqiang Min, Dongzhi Wei. Characterization, efficacy, pharmacokinetics, and biodistribution of 5 kDa mPEG modified tetrameric canine uricase variant. International Journal of Pharmaceutics, 2012, 430(1-2):307-317.

4.       Chun Zhang, Kai Fan, Xuefeng Ma. Structural confirmation of a novel nondisulfide covalent cross-linked dimer in uricase family. Abstracts of Papers of the American Chemical Society, 2011, 241:286-BIOT.

5.       Chun Zhang, Kai Fan, ZhenMin Chen, Hua Luo. Preclinical evaluation of 5 kDa mPEG modified canine uricase. 2011 AAPS National Biotechnology Conference, 2011, T2045.

6.       Kai Fan, Yong Chen, Zengtao Zhang, Chun Zhang. Disulfide-bond mutant of human keratinocyte growth factor: Its therapeutic potential with structural confirmation. Abstracts of Papers of the American Chemical Society, 2011, 507-BIOT.

7.       Qing Chen, Kai Fan, Lin Wang, Lan Luo, Chun Zhang. The study on PEGylation and biological activity of insulinotropic analogues. Pharmaceutical Biotechnology, 2011, 18(2):145-149 (In Chinese).